Neonatal sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. An outbreak of elizabethkingia meningoseptica neonatal meningitis. Laboratory methods for the diagnosis of meningitis caused by neisseria meningitidis, streptococcus pneumoniae, and haemophilus influenzae. Pdf neonatal meningitis is a severe acute infectious disease of the central nervous. Acute bacterial meningitis beyond the neonatal period.
Neonatal bacterial meningitis is an uncommon but devastating infection. Neonatal sepsis is a clinical syndrome characterized by systemic signs of. Selected references these references are in pubmed. The purpose of this study is to examine the results of repeat lumbar puncture in infants with initial positive cerebrospinal fluid csf cultures in order to determine the clinical characteristics. Antibiotic treatment of suspected neonatal meningitis. Choice and duration of antimicrobial therapy for neonatal. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Signs and symptoms of sepsis are nonspecific, and empiric antimicrobial therapy is promptly initiated after obtaining appropriate cultures. This may not be the complete list of references from this article. They noted the absence of clinical trials with third generation cephalosporins that showed an.
Meningitis is more common in the neonatal period than any other time in life and is an important cause of morbidity and mortality globally. Is your newborn showing signs of neonatal meningitis. Principles and practice of pediatric infectious diseases. Pdf pathophysiology of neonatal acute bacterial meningitis. Treatment of neonates with suspected sepsis or meningitis should. Twelve years ago an annotation was published in archives of disease in childhood regarding the antibiotic treatment of suspected neonatal meningitis. This is a pdf file of an unedited manuscript that has been accepted for. Get the facts and find out how you can prevent this serious infection. The greatest risk of acquiring meningitis is in the neonatal period. Neisseria meningitidis is one of the major causes of meningitis in children and adolescents, but it is rarely found during the neonatal period. Repeat lumbar punctures in infants with meningitis in the.
Second edition 2011 this manual summarizes laboratory techniques used in the isolation and identification and characterization of neisseria meningitidis the meningococcus, streptococcus pneumoniae the pneumococcus and haemophilus influenzae from the. If there are clinical signs suggestive of associated sepsis or meningitis, central nervous system infection should be rule out by doing a. The authors recommended the use of cephalosporins rather than chloramphenicol and advocated intraventricular aminoglycoside treatment in selected cases. Despite the majority of the burden occurring in the developing world, the majority of the existing literature originates from wealthy countries. The full text of this article is available as a pdf 4k. Laboratory methods for the diagnosis of meningitis caused by neisseria meningitidis, streptococcus pneumoniae, and haemophilus influenzae w h o m a n ua l, 2n d e d i t ion1 1 the first edition has the who reference whocdscsredc99. Here, we describe a neonate with meningococcal sepsis who was admitted to the hospital on postnatal day 10, and we discuss the clinical features of neonatal infection with n. Choice and duration of antimicrobial therapy for neonatal sepsis. In general, acute bacterial infections in neonates are divided into earlyonset first 7 days and lateonset sepsis.